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The scientific campus is located near Miramare Castle, about 6 km from downtown Trieste and enjoys its rather picturesque setting on the hills facing the Adriatic sea.

Other neighboring institutions are the International Centre for Theoretical Physics (ICTP) and the Department of Theoretical Physics (DFT) of the University of Trieste.
The SISSA-ISAS school that also hosts permanent staff of the INFN (Istituto Nazionale di Fisica Nucleare) and INFM (Istituto Nazionale di Fisica della Materia) and enjoys a close collaboration with the International Center for Genetic Engineering and Biotechnology (ICGEB).

WWF Italia ONLUS - The Miramare Marine Nature Reserve

Science Centre - Immaginario Scientifico

Trieste International Foundation for the Progress and Freedom of Science

TWAS - The Academy of Sciences for the Developing World